Personal introduction

Xin Dongis an associate professor. His main research interest is the development and application of new methods of metabolomics and proteomics based on mass spectrometry platform. In recent years, he has mainly applied omics methods to screen new biomarkers and study their mechanisms for health management and disease prevention in large populations. He is currently a member of the Osteoporosis Research Group of the Youth Committee of the Chinese Society of Osteoporosis, a standing member of the Osteoporosis Professional Committee of the Shanghai Society of Integrated Traditional Chinese and Western Medicine, and a standing member of the Osteoporosis Expert Committee of the Geriatric Society of the Chinese Society of Gerontology and Geriatrics. Special Reviewer of Journal of Pharmaceutical and Biomedical Analysis, Journal of Chromatography B, Scientific Reports and other international professional journals on drug Analysis. As the principal, he has presided over a number of scientific research projects, including the National Natural Science Foundation of China, the Shanghai Municipal Natural Science Foundation, the Biomedical Support Project of Shanghai Science and Technology Commission, and the theme project of the National Defense Science and Technology Innovation Special Zone of the Science and Technology Commission of the Military Commission, with a research fund of nearly 5 million yuan. He won the first prize of integrated traditional Chinese and western medicine in Shanghai. Published more than 30 SCI papers as the first or corresponding author in the past five years.

Main research areas

Development and application of new methods of metabolomics and proteomics based on mass spectrometry platform, screening and mechanism research of novel biomarkers for health management and disease prevention of large population using omics methods.

Representative Academic Achievements

The paper

1.Songyan Gao#, Rui Yang#, Zhongjiang Peng, Hongtao Lu, Na Li, Jiarong Ding, Xingang Cui, Wei Chen*, Xin Dong*.Metabolomics analysis for hydroxyl-L-proline-induced calcium oxalate nephrolithiasis in rats base on ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry. Sci. Rep. 2016 Jul 22;At 6:30, 142.

2.Li Su#, Hongxia Zhao#, Xiuhua Zhang, Ziyang Lou*,Xin Dong*. UHPLC-QO-TOFMS based serum metabonomics revealed perturbations of ischemic ischemic stroke in rat models. Mol. Biosyst. 2016,12,1831.

3.Hongxia Zhao#, Hongli Du#,Min Liu#, Songyan Gao, Na Li, Yufan Chao, Ruiqing Li, Wei Chen*, Ziyang Lou*,Integrative Proteomics -- Metabolomics Strategy for Pathological Mechanism of Vascular Depression Mouse Model. Journal of Proteome Research. 2018 Jan 5;17 (1) : 656-669.

4.Li Su#, Na Li#, Hua Tang, Ziyang Lou, Xiaodan Chong, Chenxi Zhang, Jiacan Su*, Kupffer cell-derived TNF-α promotes hepatocytes to produce CXCL1 and immunized neutrophils in response to necrotic cells. Cell Death &Disease.2018 02 23;9 (3).

5.Chao Yufan#,GaoSongyan#,WangXuelei#,Li Na,Zhao Hongxia,Wen Xiaofei*,Lou Ziyang*,Dong Xin*. Untargeted lipidomics based on UPLC-QTOF-MS/MS and structural characterization reveals dramatic compositional changes in serum and renal lipids in mice with glyoxylate-induced nephrolithiasis. Journal of Chromatography B. 2018 Sep 15;1095:258-266. Doi: 10.1016 / j.j chromb. 2018.08.003

Social Academic Part-time Job

Member of Osteoporosis Research Group of Youth Committee of Chinese Society of Osteology

Standing member of Osteoporosis Professional Committee of Shanghai Association of Integrated Traditional Chinese and Western Medicine

Standing member of orthopedic (Shanghai) expert committee of geriatrics branch of Chinese gerontology and geriatrics society